What is NAD+?
NAD or nicotinamide adenine dinucleotide levels are something that exists naturally in our bodies. NAD+ and NADH are enzymes vital to our metabolism.
They aid in moving electrons from one cell to the next. This is how metabolism and energy levels in the body are controlled.
They do this because they affect SIRT 1, which is key to improving resistance to physical and psychological illnesses.
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How Does NAD Effect Your Body?
NAD IV therapy is designed to replace depleted levels in your body hence it is commonly known as the energy molecule.
NADH is a vital part of the Krebs Cycle also known as the citric acid cycle. Thisis the sequence of chemical reactions that take saved energy from carbs, fats and protein in our bodies. And plays an important role in dissolving and releasing stored energy into our bodies for us to use.
Why do I need NAD IV treatment?
NAD levels get lower naturally as we age, but poor nutrition and obesity contribute. As we get older, NAD in our bodies is lost.
Alcoholism and drug addiction can influence NAD levels, making it more difficult to use niacin naturally occurring in our diet.
A NAD infusion is the most effective and quickest way to replenish the levels in your body. This can contribute to a number of age and substance abuse related conditions. These vary from depression, withdrawal and chronic fatigue to obesity and skin problems.
Dr Joseph Goldberger first studied NAD levels in human beings on behalf of the Surgeon General of the United States. They were hoping to treat the disease Pellagra, which is caused by not enough niacin leading to NAD deficiency. They found the problem was caused by restricted diet, obesity, malnutrition and alcohol abuse and drug abuse.
There are a few ways to increase the level of NAD+ and NADH in your body and experience the health improvement it brings.
The most effective treatments are available in our NAD clinics in Glasgow and London. Your therapy will be overseen by medical professionals with years of experience in NAD.
NAD IV Therapy At Our Clinic
Also known as a NAD drip, this is an infusion of the enzymes that your body makes into increased NAD levels.
A NAD infusion is the most effective way of taking NAD+ as it goes directly into your bloodstream. This will be administered at a NAD clinic under the supervision of a doctor specialising in NAD IV treatment.
NAD drips usually take 1-2 hours or longer to complete. During this time, you can sit or lie down and relax.
You will usually return for two or four more sessions after your first appointment. These will be spaced out to make the most of the initial impact of NAD IV treatment.
NAD’s immediate effect is increased energy levels and reduced cravings for those with alcohol dependence.
NAD Injections, also known as a NAD shot, are also available. They are delivered into the muscle rather than the bloodstream; it is less effective than NAD IV.
Although taking nicotinamide mononucleotide, the precursor available orally, is safe and has some effect, it is much less so than both NAD IV and NAD injection.
This is because the absorption of any nutrient through the stomach is much less effective than having it introduced through the bloodstream. This means that NAD supplements increase NAD levels at a much-reduced level than a NAD drip.
NAD Drip For Oxidative Stress
The main purpose of NAD treatment is to reduce oxidative stress. Oxidation is a normal part of your body function. However, oxidative stress happens when the balance of free radicals and antioxidants is disrupted.
Most people have heard of antioxidants which prevent or slow cell damage. Free radicals are important too, they can protect us against disease.When free radicals become higher in numbers this balance is disrupted and cells can be damaged.
NAD is a directly operating antioxidantwhich can help to restore the balance of oxidation in the body. Imbalance in antioxidants is caused by a variety of issues the main concerns are listed below.
NAD+ IV Alcohol Detox
One of the causes of low NAD+ levels in the body is alcohol abuse. The body uses NAD+ when it breaks down alcohol in the body. Studies show that during alcohol binges, NAD levels drop significantly.
Alcohol abuse is the second most common cause of Pellagra or NAD deficiency after malnutrition. This causes a breakdown in the relationship between sirtuin and NAD+, which leads in turn to inflammation and damage to the liver.
NAD IV Drug Detox
All addictions are formed in the brain reward pathways and are considered a neuropsychiatric condition. This means they are caused by neurological (physical brain conditions) and psychiatric (the brain working abnormally) issues.
One of the main parts of the brain affected by drug misuse is the dopamine pathway. The use of drugs can lead to lesions in the brain in these and other pathways.
NAD+ treatment has been shown to counteract the deterioration caused to the dopamine pathways by drug or alcohol abuse.
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NAD IV Long Covid
With more and more people emerging from the pandemic with chronic long-term symptoms, there is hope that NAD+ might provide the answer.
One of the main issues with long covid is fatigue. NAD IV supplements have been shown in clinical trials to improve the symptoms of those with chronic fatigue syndrome. The hope is that treatment with NAD+ will give an energy boost to those struggling with post-viral fatigue.
Scientists believe that the inflammatory response to covid 19 infection is one of the reasons for severe reactions and long-term symptoms. Given the role of NAD+ in reducing inflammation, NAD IV therapy is a viable option to help those with long-covid symptoms.
NAD IV Depression
There are strong links between niacin generally and psychological disorders. One of the side effects of NAD deficiency is depression and some of its associated symptoms: fatigue, apathy and memory loss.
Numerous studies show that NAD+ supplementation can improve depressive symptoms in a large proportion of people treated. There is substantial speculation about the causes and solutions to depression. There is a growing body of evidence that NAD and SIRT 1 deficiency may be a factor in causing depression.
Depression can be a vicious cycle, and NAD can help by encouraging many natural actions such as exercise and better health that improve this condition.
Better energy levels and mental clarity can give you a much-needed boost to your mood. Also, NAD IV relieves the symptoms of depression, which can be a stepping stone to recovery.
NAD IV Anxiety
Many of the same principles apply to anxiety as depression. Although they might seem different, they occur together frequently, and one often leads to the other.
There is evidence that NAD supplementations can not only elevate your mood but also reverse some of the experiences of anxiety. The downwards cycles of depression and anxiety can deplete the reward and happiness-creating chemicals in the brain (neurotransmitters). NAD IV can help to refresh these and put you on the road to recovery.
NAD IV Obesity
A poor performing metabolism can be a chronic issue that only spirals in time. Those with a low metabolism may gain weight easily, making exercising more difficult and exhausting.
An improvement in energy levels can help you start a healthier lifestyle. Getting started is often the biggest hurdle.
Unlike other weight loss treatments, NAD focuses on helping you to lead a healthier and fitter life rather than altering how your body processes fat. Treatments like this are temporary and don’t help with the problem long-term.
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0527-8 Implications of altered NAD metabolism in metabolic disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278809/ Sobriety and Satiety: Is NAD+ the Answer?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036060/ Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
https://pubmed.ncbi.nlm.nih.gov/6407471/ The effect of alcohol stress on nicotinamide adenine dinucleotide (NAD+) levels in Drosophila
https://pubmed.ncbi.nlm.nih.gov/31080405/ SIRT2, ERK and Nrf2 Mediate NAD + Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions
https://pubmed.ncbi.nlm.nih.gov/10071523/ Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515/#:~:text=NAD%20regulates%20immune%20function%20and,against%20acute%20injury%20in%20kidney. Therapeutic potential of NAD-boosting molecules: the in vivo evidence
https://pubmed.ncbi.nlm.nih.gov/25596911/ Antidepressants may lead to a decrease in niacin and NAD in patients with poor dietary intake
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-020-00703-4 Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616312/ Targeting SIRT1 to improve metabolism: all you need is NAD+?